If you’ve ever had to deal with a lice infestation, you know how frustrating it can be to get rid of both lice and their nits (eggs). A common question many people ask is: Can I kill nits without combing? The idea of skipping the tedious combing process may sound tempting, but the reality may surprise you. Do Any Products Kill Nits Without Combing? Many over-the-counter lice treatments claim to kill both lice and nits, but not all products are equally effective against eggs.